Endocrine Abstracts

Objective: The aim of this study is to determine serum concentrations of adiponectin (ApN), leptin and ghrelin in different stages of anorexia nervosa (AN) and to evaluate their relationships between biochemical, hormonal and anthropometric parameters.Materials and methods: The study is composed of four groups. Group 1: Treatment-naïve patients with a recent diagnosis of AN (n: 19), Group 2: The weight recovered (10% increase in body weight c...

Background: Enviromental factors such as life style changes and dieatary factors become more important on the background of coronary artery disease (CAD). The thiols were the main part of the non-enzymatic antioxidant system in the body and they are the first defensive molecules in elimination of oxidant agents. As a result, thiol levels may be an earlier indicator for CAD. There is limited data on the relation of dietary factors with thiol/disulfide homeostasis in patients wi...

Background: Despite the efforts to reduce smoking, unfortunately there is a common belief in society to avoid smoking cessation or quitting smoking for weight control. As well as many negative effects of smoking, people continue to smoke instead of diet and life change. Nicotine plus high fat diet (HFD) induces intramyocellular lipid accumulation and mitochondrial abnormalities in obese mice. There is limited data in the relation of dietary fat content and metabolic syndrome i...

Introduction: Prolactinoma is the prolactin secreting tumor of the pituitary gland which exerts mainly hypogonadal complaints and sometimes symptoms due to mass effect. Meanwhile it was mentioned to cause metabolic abnormalities such as increased fasting plasma glucose (FPG), Low Density Lipoprotein(LDL) cholesterol and triglycerides(TG). We studied whether some of these metabolic parametres of prolactinoma patients could be changed after the therapy.Met...

Objective: Euthyroid patients undergoing thyroidectomy were reported to gain weight than their matched counterparts. The etiology is still unknown. Serum adiponectin and leptin levels are related to fat mass and thyroid hormones. We aimed to evaluate the influence of thyroidectomy on body composition, serum adiponectin, leptin levels in euthyroid obese and non-obese patients who underwent total thyroidectomy for goiter.Methods: We conducted a prospective...

Objective: Rosacea is an inflammatory dermatosis. Telangiectasias, edema, erythema, and acneiform eruptions are the main symptoms. Several genetic and environmental factors have been linked to rosacea; however, the etiology of the disease is still not known. It is considered a systemic disease rather than a skin disorder. Endocrine-disrupting chemicals are substances people are exposed to through water, food, self-care products, and the environment. They interfere with normal ...

Introduction: Primary hyperparathyroidism (PHPT) clinic occurs when the parathyroid glands secrete excess parathormone (PTH) due to hyperplasia, adenomatous or carcinomatous change. In the pathogenesis of the disease, dysregulation has been observed in extracellular signal-regulated 1/2 (ERK 1/2) pathways from the mitogen activated protein kinase (MAPK) family, c-Jun N-terminal kinase (JNK) pathways, and phosphatidylinositol-3 kinase (PI3K) pathways. Progranulin (PGRN) is a gl...

Introduction: Insulin antibodies, developed in patients treated with exogenous insulin, might affect glycemic control due to their tendency to bind and/or release insulin in an unpredictable fashion. It is reported to be caused by immunoglobulin G-derived insulin antibodies. Insulin antibodies induced by exogenous insulin in diabetic patients is associated with hypersensitivity reactions, glycemic variability mainly with insulin resistance/ hyperglycemia or hypoglycemia. We re...

Introduction: Gestational Diabetes Mellitus (GDM) is associated with maternal and perinatal morbidity. Follistatin-like 1 (FSTL-1), also known as TGFB-beta-stimulated clone 36 (TSC-36), is a glycoprotein cardiokine reported to be associated with insulin resistance and inflammatory processes. To date, there is no study evaluating the effect of FSTL-1 gene polymorphism on the development of GDM in the literature. In this study, we aimed to investigate the effect of serum FSTL-1 ...

Objective: The finding of new biomarkers is needed to have an early diagnosis of breast cancer. In this study we evaluated serum levels of carboxylated osteocalcin (OC) and uncarboxylated osteocalcin(UcOC), CRP as a diagnostic biomarker for breast cancer.Design and methods: Blood samples of 39 women with newly diagnosed breast cancer with stage I were obtained before surgery and 39 age and BMI matched health women were selected as controls.<p class="...